GLP-1 Common Side Effects

GLP-1 (glucagon-like peptide-1) agonists, more commonly known as semaglutide, Wegovy, Ozempic, Monjarno or Zepbound are medications often used to manage type 2 diabetes and obesity. While they can be effective, they may also have side effects. Here are some common side effects and tips on how to potentially avoid or mitigate them:

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April 7, 2025 3:37 am

Common side effects

1.Nausea and Vomiting: Many users report gastrointestinal issues, especially when starting the medication.

2. Diarrhea or Constipation: Changes in bowel habits can occur.

3. Loss of Appetite: This can be beneficial for weight loss but may lead to inadequate caloric intake.

4. Headache: Some may experience headaches as a side effect.

5. Dizziness: This can happen, particularly if blood sugar levels drop.

6. Injection Site Reactions: Redness or irritation at the injection site can occur.

Tips to Avoid or Mitigate Side Effects

1. Start with a Low Dose: Gradually increasing the dose can help your body adjust and minimize nausea and gastrointestinal discomfort.

The clinical guidance for GLP-1 dose titration is every 4 weeks. Increasing dose is only required until patient is achieving adequate weight loss. Your provider should not need to titrate your dose up if you are loosing weight at lower doses.

2.Take with Food: Consuming the medication with meals can help reduce nausea.

3. Stay Hydrated: Drinking plenty of water can help alleviate some gastrointestinal symptoms.

4. Small, Frequent Meals: Eating smaller meals more frequently can help manage appetite and reduce nausea.

5. Monitor Blood Sugar Levels: Regularly checking your blood sugar can help you avoid hypoglycemia, which might contribute to dizziness and headaches.

6. Consult with Healthcare Provider: Regular discussions with your healthcare provider can help in managing side effects and adjusting the treatment plan if necessary.

7. Be Patient: Side effects often diminish over time as your body adjusts to the medication.

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